Computational + Experimental Discovery

AI Drug Discovery Services

Computational Drug Discovery + Wet-Lab Validation

CycloGen combines AI-powered computational drug discovery with wet-lab capabilities delivered through our CRO partner network. Start with a biological target and build a discovery program combining structural intelligence, therapeutic design, computational candidate prioritization and experimental validation.

Private AI Computational Design CRO Network Wet-Lab Validation
CycloGen AI
Biological Target
→
Structural Intelligence
→
AI Therapeutic Design
→
Computational Prioritization
→
CRO Partner Network
Experimental Validation
→
Experimental Evidence

Integrated Drug Discovery

Computational Discovery Meets Experimental Science

A computational candidate remains a hypothesis until experimental evidence supports it. CycloGen connects AI-assisted discovery with experimental capabilities available through our CRO network, creating a coordinated path from target analysis and therapeutic design to laboratory investigation.

Instead of assembling disconnected computational tools and experimental vendors independently, biotechnology teams can build a coordinated computational-to-experimental discovery program.

One Discovery Program. Computational Design + Experimental Validation.

Choose the Discovery Program That Fits Your Science

01 — Private AI Platform

Private Computational Drug Discovery

For organizations with their own scientific and experimental capabilities.

  • Target analysis
  • Structure prediction
  • Druggability analysis
  • Protein design (nanobodies, antibodies, mini-binders, peptides)
  • Molecular docking
  • Candidate prioritization
Explore the Platform

02 — Computational Design Program

Bring CycloGen a target and build a computational discovery program

Target → Structure → Druggability → Design → Complex → Analysis → Shortlist

Potential modalities: Protein therapeutics, Nanobodies, Antibodies, Mini-binders, Peptides, Small-molecule workflows

Deliverable: A traceable computational candidate set prepared for experimental investigation.

Discuss a Design Program

Flagship Integrated Service

03 — AI + Wet-Lab Validation

Computational Design + CRO Experimental Validation

Target → AI Design → Computational Screening → Candidate Shortlist → CRO Production → Experimental Assays → Results

Depending on project scope and CRO capability, experimental services can include:

  • Gene synthesis & protein expression
  • Protein purification & candidate production
  • Biochemical & binding assays
  • Biophysical characterization
  • Candidate screening
  • Structural biology support

Laboratory services are delivered through participating independent CRO partners and scoped according to the scientific requirements of each program.

Build a Validation Program

04 — Integrated Discovery Program

AI + Design + CRO Wet Lab — From Target to Experimental Evidence

Target → CycloGen AI → Candidate Design → Computational Prioritization → CRO Experiment → Experimental Data → Next Design Cycle

Designed for biotechnology organizations seeking a coordinated computational-to-experimental discovery workflow without building every capability internally.

Discuss an Integrated Program

AI + CRO Discovery Bundles

Build the Experimental Program Around the Science

Protein Discovery

CycloGen AI + Protein Design + CRO Protein Services

Target → Computational Design → Structural Assessment → Candidate Prioritization → Gene Synthesis → Protein Expression → Purification → Characterization

Applications: Nanobody discovery, Antibody discovery, Mini-binder discovery, Protein therapeutic design

Structural Biology

CycloGen Structural Intelligence + CRO Structural Services

Structure → Computational Analysis → Interaction Hypothesis → Candidate Selection → CRO Structural/Biophysical Study → Evidence

AI-Assisted Drug Discovery

CycloGen AI + Computational Screening + CRO Validation

Target → Structure → Design → Computational Screening → Candidate Prioritization → CRO Experiments → Results

CRO Partner Network

Computational Discovery. Experimental Reach.

CycloGen works with CRO partners to connect computational drug discovery with specialized experimental capabilities. Our CRO relationships include capabilities in major biotechnology hubs, allowing appropriate experimental services to be integrated with CycloGen computational discovery programs.

Cambridge

United Kingdom

Experimental and protein-service partner capabilities

Boston

United States

Biotechnology and experimental partner capabilities

Built for Emerging Biotech

Big Discovery Capability Without Building Everything In-House

Emerging biotechnology companies can have exceptional biology, proprietary targets and valuable therapeutic hypotheses without the infrastructure of a large pharmaceutical organization. Building computational infrastructure, recruiting specialized AI teams, establishing protein-production capabilities and coordinating multiple experimental providers can consume substantial time and capital.

CycloGen provides another path.

Your Biology + CycloGen AI Compute + Computational Design + CRO Experiment = Integrated Discovery Program

Connect Computational Design With Experimental Evidence

Design
→
Computational Assessment
→
Select
→
Experiment
→
Measure
→
Refine
↺

The objective is not simply to generate more molecules or protein sequences. It is to reduce a large design space to experimentally testable candidates, measure what happens in the laboratory, and use that evidence to inform subsequent discovery decisions.

Keep Computational Discovery Closer to Your IP

Customer-Controlled Infrastructure
Proprietary Target ↓ CycloGen AI ↓ Candidate Generation ↓ Computational Analysis ↓ Candidate Prioritization
→ Selected Candidates
CRO Experimental Workflow
Candidate Production ↓ Assay / Characterization ↓ Experimental Data

Private computational discovery does not require every intermediate computational artifact to become part of an external experimental workflow. The information required for a particular experiment can be transferred according to the customer's program, confidentiality requirements and CRO agreements.

From Scientific Question to Discovery Program

01

Discuss the Target

Understand the biology, therapeutic modality and scientific question.

02

Define the Program

Select appropriate CycloGen workflows and candidate evaluation strategy.

03

Design & Prioritize

Generate and computationally evaluate candidate designs.

04

Experiment

Move selected candidates into appropriately scoped CRO experimental program.

05

Learn & Iterate

Use experimental evidence to inform subsequent scientific decisions.

Frequently Asked Questions

What are AI drug discovery services?

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AI drug discovery services combine computational methods including structure prediction, molecular design, docking, and candidate prioritization with optional wet-lab validation to accelerate therapeutic discovery programs.

Can AI drug discovery be combined with wet-lab validation?

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Yes. CycloGen offers integrated discovery programs that combine computational candidate design with experimental validation through our CRO partner network.

Does CycloGen provide protein design services?

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Yes. CycloGen supports protein design workflows including nanobody design, antibody discovery, mini-binder design, and peptide design as part of computational discovery programs.

Can CycloGen AI run on-premise?

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Yes. CycloGen can be deployed within customer-controlled infrastructure, allowing organizations to run computational discovery workflows closer to their proprietary research data.

Does CycloGen operate the wet lab?

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CycloGen provides the computational platform and discovery workflows. Wet-lab services within bundled programs are performed by participating independent CRO partners.

Who owns the therapeutic IP?

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IP ownership, confidentiality and data-handling terms are governed by the applicable agreements for each engagement. Customers should review the relevant contractual terms before beginning a program.

Start With the Science

Bring Us a Target. Build the Right Discovery Program Around It.

Whether you need private computational infrastructure, therapeutic design, candidate prioritization, wet-lab validation or an integrated AI + CRO discovery program, CycloGen can structure the engagement around the scientific objective.

Discuss Your Target Contact CycloGen
AI Drug Discovery Protein Design Private Deployment CRO Network Wet-Lab Validation